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HRID853578

反应详情

EQUATION

反应方程式

HRID 853578 的结构方程式

REACTANTS

反应物

3
结构：CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F
HCID151348

Tri(dimethylamino)benzotriazol-1-yloxyphosphonium hexafluorophosphate

C12H22F6N6OP2

结构：N[C@@H]1C[C@@H]1F
HCID10313105

(1R,2S)-2-Fluorocyclopropan-1-amine

C3H6FN

结构：CCNC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(C(=O)O)cc23)cc1F
HCID22936395

未命名化合物

PRODUCTS

生成物

1
结构：CCNC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(C(=O)N[C@@H]4C[C@@H]4F)cc23)cc1F
HCID67203132

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

4-(4-(3-Ethylureido)-3-fluorophenoxy)-7-methoxyquinoline-6-carboxylic acid (20 mg) was treated with cis-2-fluorocyclopropylamine, triethylamine and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate in the same manner as Example 634, to obtain the title compound (9 mg) as a solid.