HCID 22936864, compound → HCID 135829402, compound

HRID 853581Notes

Reaction equation

HRID 853581 reaction equation
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][C:23]([NH:26][C:27]([NH:29][CH2:30][CH3:31])=[O:28])=[C:22]([CH3:32])[CH:21]=3)=[CH:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[C:33]#[N:34])C1C=CC=CC=1>O1CCCC1.[C].[Pd]>[C:33]([C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][C:9]=1[OH:8])[N:16]=[CH:15][CH:14]=[C:13]2[O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]([NH:29][CH2:30][CH3:31])=[O:28])=[C:22]([CH3:32])[CH:21]=1)#[N:34]

Participants

4

Reactant 1

HCID 22936864HCID 22936864, compound

Product 1

HCID 135829402HCID 135829402, compoundYield 65.6%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

In the same manner as Production Example 301-2, N-(4-(7-benzyloxy-6-cyanoquinolin-4-yloxy)-2-methylphenyl)-N′-ethylurea (0.8 g) was debenzylated in tetrahydrofuran using palladium-carbon, to obtain the title compound (0.42 g) as a solid.

Sources & evidence

ORD record
ord-f83c866a6e4446be811cccad8cb8acc9
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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