Methylamine → HCID 22936664, compound

HRID 853593Notes

Reaction equation

HRID 853593 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:30][CH3:31])=[C:24]([C:27](=[O:29])[NH2:28])[CH:25]=4)[N:20]=[CH:19][CH:18]=3)=[CH:12][C:11]=2[C:32]([F:35])([F:34])[F:33])C=CC=CC=1.[CH3:37][NH2:38]>>[C:27]([C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][C:23]=1[O:30][CH3:31])[N:20]=[CH:19][CH:18]=[C:17]2[O:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:8]([NH:38][CH3:37])=[O:7])=[C:11]([C:32]([F:34])([F:33])[F:35])[CH:12]=1)(=[O:29])[NH2:28]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 67202368HCID 67202368, compound

Product 1

HCID 22936664HCID 22936664, compound

Procedure

After adding [4-(6-carbamoyl-7-methoxy-4-quinolyl)oxy-2-trifluoromethylphenyl]carbamic acid phenyl ester (25 mg) to methylamine 2N tetrahydrofuran solution (1.00 ml), the mixture was stirred for 10 minutes. The precipitated crystals were filtered out and washed with tetrahydrofuran to obtain the title compound (10 mg).

Workup

  1. filtrationThe precipitated crystals were filtered out
  2. washwashed with tetrahydrofuran

Sources & evidence

ORD record
ord-e96fc7c81d364ef388f27a99621490f2
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

Loading…