HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 7-[(4-fluorophenyl)methyl]-9-hydroxy-5,6-dimethoxy-6H-pyrrolo[3,4-g]quinolin-8-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 7-[(4-fluorophenyl)methyl]-6,9-dihydroxy-5-methoxy-6H-pyrrolo[3,4-g]quinolin-8-one | HCID 10383471 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-[(4-fluorophenyl)methyl]-9-hydroxy-5,6-dimethoxy-6H-pyrrolo[3,4-g]quinolin-8-one | HCID 11726510 | — |
Reaction Steps
A solution of 21 (6.7 mg, 0.019 mmol) in a 1:1 solution of CH2Cl2:MeOH was stirred with TFA (3 μL, 0.038 mmol) at room temperature for 2 hours when complete conversion was observed by LCMS. The solution was dried in vacuo and the residue was washed with hexanes to yield 7 mg of the product 22. EI MS (m/z) 355.4 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253180B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-c1d42bc97f7f451f9c0043752017028e |
| Source note | uspto-grants-2007_08 |