Trifluoroacetic acid → HCID 86593993, compound

HRID 853639Notes

Reaction equation

HRID 853639 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[C:10](=[O:22])[CH2:9]1)=O)(C)(C)C.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>C(Cl)Cl>[F:26][C:25]([F:28])([F:27])[C:23]([O-:29])=[O:24].[F:21][C:18]1[CH:19]=[CH:20][C:15]([CH2:14][N:11]2[CH2:12][CH2:13][NH2+:8][CH2:9][C:10]2=[O:22])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23526830HCID 23526830, compound

Product 1

HCID 86593993HCID 86593993, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 34 (1.4 g, 4.5 mmol) in 6 mL of a 1:1 solution of CH2Cl2:TFA was stirred at ambient temperature for 2 hours when all of the starting materials were consumed as judged by TLC. The reaction mixtures were dried in vacuo to yield 1.5 g of 35 as a thick oil which was used in the next reaction without purification.

Workup

  1. customwere consumed
  2. customThe reaction mixtures
  3. customwere dried in vacuo

Sources & evidence

ORD record
ord-37ab0b05d25744618d92a748644702a4
Source dataset
uspto-grants-2007_08
Patent number
US07253180B2

Reaction notes

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