Iodine → 5-(But-3-en-1-yl)-1,3-difluoro-2-iodobenzene

Temperature

-70 °C

0.41 mol 1,3 difluoro-5-(3-butenyl)-benzene was added to a dry round bottom flask with 300 ml anhydrous tetrahydrofuran. After cooling under a nitrogen atmosphere to −70° C. a solution of 0.46 mol of n-butyllithium in 280 ml hexane was added. After stirring at −70° C. for 30 minutes a mixture of 0.46 mol of Iodine in 200 ml tetrahydrofuran was added slowly over 2 hours. The reaction was left to warm to room temperature overnight. The reaction was quenched by pouring onto ice/hydrochloric acid mixture. The layers were separated and the aqueous layer extracted twice with diethyl ether (2×100 ml). The combined organic layers were washed with 50 g sodium thiosulphate in 200 ml water to remove excess iodine, then with water (2×50 ml) and dried over anhydrous sodium sulphate. Removal of the solvent yielded 126 g of the title compound as a beige solid.

1. additionwas added
2. additionwas added slowly over 2 hours
3. waitThe reaction was left
4. temperatureto warm to room temperature overnight
5. customThe reaction was quenched
6. additionby pouring onto ice/hydrochloric acid mixture
7. customThe layers were separated
8. extractionthe aqueous layer extracted twice with diethyl ether (2×100 ml)
9. washThe combined organic layers were washed with 50 g sodium thiosulphate in 200 ml water
10. customto remove excess iodine
11. dry with materialwith water (2×50 ml) and dried over anhydrous sodium sulphate
12. customRemoval of the solvent

ORD record

ord-2a9b15020f494671923c6adef4593b40

Source dataset

uspto-grants-2007_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07255811B2