Water → Lactic Acid

HRID 853728Notes

Reaction equation

HRID 853728 reaction equation
[CH3:1][CH:2]1[O:9]C(=O)C(C)[O:5][C:3]1=[O:4].[CH2:11]1[O:18]C(=O)C[O:14][C:12]1=[O:13].C(Cl)(Cl)Cl.CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C)=O.O>C(Cl)Cl>[C:3]([OH:5])(=[O:4])[CH:2]([CH3:1])[OH:9].[C:12]([OH:14])(=[O:13])[CH2:11][OH:18]

Participants

7

Reactant 4

HCID 962WaterHCID 6212ChloroformHCID 71391HCID 71391, compoundHCID 6437371N,N,N-Trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-1-propanaminium

Product 2

HCID 612Lactic AcidHCID 757Glycolic Acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
40 °C

Procedure

Cationic poly(lactic acid, glycolic acid) microcarriers (cPLGA) were prepared as follows. 0.875 g of poly (D,L-lactide-co-glycolide) 50:50 polymer (Boehringer Mannheim, Indianapolis, Ind.) with an intrinsic viscosity of 0.41 dl/g (0.1%, chloroform, 25° C.) was dissolved in 7.875 g of methylene chloride at 10% w/w concentration, along with 0.3 g of DOTAP. The clear organic phase was then emulsified into 500 ml of PVA aqueous solution (0.35% w/v) by homogenization at 4000 rpm for 30 minutes at room temperature using a laboratory mixer (Silverson L4R, Silverson Instruments). System temperature was then raised to 40° C. by circulating hot water through the jacket of the mixing vessel. Simultaneously, the stirring rate was reduced to 1500 rpm, and these conditions were maintained for 2 hours to extract and evaporate methylene chloride. The microsphere suspension was allowed to cool down to room temperature with the help of circulating cold water.

Workup

  1. temperaturethese conditions were maintained for 2 hours
  2. extractionto extract
  3. customevaporate methylene chloride
  4. temperatureto cool down to room temperature with the help

Sources & evidence

ORD record
ord-2bbc4924245e45a783ee965663af9b0d
Source dataset
uspto-grants-2007_08
Patent number
US07255868B2

Reaction notes

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