HCID 12093578, compound → HCID 22935667, compound

HRID 853743Notes

Reaction equation

HRID 853743 reaction equation
[CH3:1]C1CCCC2(C(=O)CCC2)C1.[CH3:13][CH:14]1[CH2:24][CH2:23][C:17]2([C:21](=[O:22])[CH2:20][CH2:19][CH2:18]2)[CH2:16][CH2:15]1.C[Li]>>[CH3:1][C:21]1([OH:22])[C:17]2([CH2:23][CH2:24][CH:14]([CH3:13])[CH2:15][CH2:16]2)[CH2:18][CH2:19][CH2:20]1

Participants

4

Reactant 3

HCID 12093578HCID 12093578, compoundHCID 12093579HCID 12093579, compoundHCID 178418348HCID 178418348, compound

Product 1

HCID 22935667HCID 22935667, compoundYield 43%

Procedure

A mixture of 7-methylspiro[4,5]decan-1-one and 8-methylspiro[4,5]decan-1-one and methyl lithium were reacted together according to the general procedure (example 2, procedure 5) to give the title compound in 43% yield. The crude product was purified by column chromatography on silicagel (eluent: cyclohexane/ethyl acetate 29:1) and bulb-to-bulb distillation (B.p.=68° C./0.04 mbar).

Workup

  1. customwere reacted together

Sources & evidence

ORD record
ord-d9c64de3f329484bb64c036a063a8bdc
Source dataset
uspto-grants-2007_08
Patent number
US07256170B2

Reaction notes

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