反应详情

温度

75 °C

ethyl 3-(4-pyridyl)-3-oxopropionate (0.60 g), 3-amidinopyridine hydrochloride (0.54 g) and potassium carbonate (1.15 g) were added to 5 ml of ethanol, and the mixture was heated under reflux at 75° C. for 20 hours. Acetic acid was added to the reaction mixture, and the solvent was removed by distillation. The residue was added with water and then with acetic acid, and the resulting solid was separated by filtration, washed with water and ethyl acetate, and dried to obtain 0.39 g of the desired compound.

1. temperaturethe mixture was heated
2. customthe solvent was removed by distillation
3. additionThe residue was added with water
4. customwith acetic acid, and the resulting solid was separated by filtration
5. washwashed with water and ethyl acetate
6. customdried