反应详情

To a solution of methyl 3′,3′-dimethyl-3′,4′-dihydro-2′H-spiro[1,3-dioxane-2,10′-pyrimido[1,2-a]indole]-8′-carboxylate (0.200 g, 0.610 mmol) in THF (4 mL)/EtOH (4 mL) was added 1N NaOH (2 mL) and H2O (2 mL) and the reaction was refluxed for 1 hr. The reaction was quenched with 1 N HCl and extracted with EtOAc (3×). The combined organic extracts were dried over Na2SO4, filtered and concentrated to give the title compound as white solid (0.097 g, 50%). NMR (400 Mz, DMSO-d6): consistent. MS (ES+) m/z 317.3 [M+H]. m.p.: 151.1-153.3° C.

1. temperaturethe reaction was refluxed for 1 hr
2. customThe reaction was quenched with 1 N HCl
3. extractionextracted with EtOAc (3×)
4. dry with materialThe combined organic extracts were dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated