HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Chloromethyl)Cyclohexanecarbonitrile → Pyrimidoindolone, 25f
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Chloromethyl)Cyclohexanecarbonitrile | HCID 2794920 | — |
| Reactant | 5'-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one | HCID 25269014 | — |
| Product | Pyrimidoindolone, 25f | HCID 11496899 | — |
Reaction Steps
The title compound was prepared as a yellow foam from 5′-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}spiro[1,3-dioxane-2,3′-indol]-2′(1′H)-one and 1-chloromethyl-cyclohexanecarbonitrile (Syn. Comm. 20(12) 1757, 1990) using a procedure similar to that of steps 3-5 of Example 12. NMR (400 Mz, DMSO-d6): consistent. MS: (ES−) m/z 492 [M−H]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07256198B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-4a6eb64f4ed24059bfe418b45805a940 |
| Source note | uspto-grants-2007_08 |