1-Methyl-4-[(2S)-pyrrolidin-2-ylmethyl]piperazine → 5-({(2S)-2-[(4-methylpiperazin-1-yl)methyl]pyrrolidin-1-yl}sulfonyl)-1H-indole-2,3-dione

HRID 853915Notes

Reaction equation

HRID 853915 reaction equation
[O:1]=[C:2]1[C:10](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:12](Cl)(=[O:14])=[O:13])[CH:8]=2)[NH:3]1.[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([CH2:23][C@@H:24]2[CH2:28][CH2:27][CH2:26][NH:25]2)[CH2:19][CH2:18]1>>[CH3:16][N:17]1[CH2:18][CH2:19][N:20]([CH2:23][C@@H:24]2[CH2:28][CH2:27][CH2:26][N:25]2[S:12]([C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[NH:3][C:2](=[O:1])[C:10]3=[O:11])(=[O:14])=[O:13])[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 132751161-Methyl-4-[(2S)-pyrrolidin-2-ylmethyl]piperazineHCID 159089472,3-Dioxoindoline-5-sulfonyl chloride

Product 1

HCID 589325865-({(2S)-2-[(4-methylpiperazin-1-yl)methyl]pyrrolidin-1-yl}sulfonyl)-1H-indole-2,3-dione

Procedure

The title compound was prepared from 2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonylchloride and 1-methyl-4-[(2S)-pyrrolidin-2-ylmethyl]piperazine according to a procedure similar to that of step 1 of Example 12. NMR (400 Mz, DMSO-d6): consistent.

Sources & evidence

ORD record
ord-4345caf451e74abd8051002e0bbe0407
Source dataset
uspto-grants-2007_08
Patent number
US07256198B2

Reaction notes

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