HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-[(2S)-pyrrolidin-2-ylmethyl]piperazine → 5-({(2S)-2-[(4-methylpiperazin-1-yl)methyl]pyrrolidin-1-yl}sulfonyl)-1H-indole-2,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-[(2S)-pyrrolidin-2-ylmethyl]piperazine | HCID 13275116 | — |
| Reactant | 2,3-Dioxoindoline-5-sulfonyl chloride | HCID 15908947 | — |
| Product | 5-({(2S)-2-[(4-methylpiperazin-1-yl)methyl]pyrrolidin-1-yl}sulfonyl)-1H-indole-2,3-dione | HCID 58932586 | — |
Reaction Steps
The title compound was prepared from 2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonylchloride and 1-methyl-4-[(2S)-pyrrolidin-2-ylmethyl]piperazine according to a procedure similar to that of step 1 of Example 12. NMR (400 Mz, DMSO-d6): consistent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07256198B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-4345caf451e74abd8051002e0bbe0407 |
| Source note | uspto-grants-2007_08 |