3,4,5-Trimethoxybenzaldehyde → HCID 85326795, compound

HRID 853936Notes

Reaction equation

HRID 853936 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:7]=[CH:6][C:5]=1[O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[O:3].[CH3:22][O:23][C:24]1[CH:25]=[C:26]([CH:29]=[C:30]([O:34][CH3:35])[C:31]=1[O:32][CH3:33])[CH:27]=O>>[F:21][C:18]([F:19])([F:20])[CH2:17][O:16][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[CH:27][C:26]1[CH:29]=[C:30]([O:34][CH3:35])[C:31]([O:32][CH3:33])=[C:24]([O:23][CH3:22])[CH:25]=1

Participants

3

Reactant 2

HCID 68583,4,5-TrimethoxybenzaldehydeHCID 27360731-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one

Product 1

HCID 85326795HCID 85326795, compound

Procedure

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and 3,4,5-trimethoxybenzaldehyde (124 mg, 0.633 mmol) similar to Example 6 and isolated as a bright yellow solid (120 mg, 38%), 1H NMR (CDCl3): 7.65 (d, J=15.6 Hz, 1H), 7.42 (d, J=15.6 Hz, 1H), 7.34 (d, J=3.3 Hz, 1H), 7.12 (dd, J=3.3, 9.0 Hz, 1H), 6.93 (d, J=9.0 Hz, 1H), 6.85 (s, 2H), 4.48-4.34 (m, 4H), 3.90 (d, J=1.8 Hz, 9H).

Sources & evidence

ORD record
ord-9e695b53d228444f929ad284fd14c10b
Source dataset
uspto-grants-2007_08
Patent number
US07256219B2

Reaction notes

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