3-Methoxybenzaldehyde → HCID 85326139, compound

HRID 853937Notes

Reaction equation

[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:7]=[CH:6][C:5]=1[O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[O:3].[CH:22](=O)[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([O:29][CH3:30])[CH:24]=1>>[F:21][C:18]([F:19])([F:20])[CH2:17][O:16][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[CH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([O:29][CH3:30])[CH:24]=1

Participants

Reactant 2

HCID 115693-Methoxybenzaldehyde

HCID 27360731-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one

Product 1

HCID 85326139HCID 85326139, compound

Procedure

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and m-anisaldehyde (77 ul, 0.633 mmol) similar to Example 6 and isolated as a light yellow solid (74 mg, 27%). 1H NMR (CDCl3): 7.67 (d, J=15.6 Hz, 1H), 7.44 (d, J=15.6 Hz, 1H), 7.34 (s, 1H), 7.30 (dd, J=2.4, 5.7 Hz, 1H), 7.18 (d, J=7.5 Hz, 1H), 7.11 (dd, J=3.2, 8.9 Hz, 2H), 6.97 (dd, J=0.9, 2.7 Hz, 1H), 6.93 (d, J=9.0 Hz, 1H), 4.44-4.33 (m, 4H), 3.83 (s, 3H).

Sources & evidence

ORD record: ord-1fe839d7f20b4601a4dfd5210015b4a4
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07256219B2

Reaction notes

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