1-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one → HCID 90912329, compound

HRID 853945Notes

Reaction equation

HRID 853945 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:7]=[CH:6][C:5]=1[O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[O:3].[F:22][C:23]1[C:30]([F:31])=[C:29]([C:32]([F:35])([F:34])[F:33])[CH:28]=[CH:27][C:24]=1[CH:25]=O>>[F:21][C:18]([F:19])([F:20])[CH2:17][O:16][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[CH:25][C:24]1[CH:27]=[CH:28][C:29]([C:32]([F:35])([F:34])[F:33])=[C:30]([F:31])[C:23]=1[F:22]

Participants

3

Reactant 2

HCID 27360731-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-oneHCID 50074682,3-difluoro-4-(trifluoromethyl)benzaldehyde

Product 1

HCID 90912329HCID 90912329, compound

Procedure

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and 2,3-difluoro-4-(trifluoromethyl)benzaldehyde (91 ul, 0.633 mmol) similar to Example 18 as a yellow solid (66 mg, 20%). 1H NMR (CDCl3): 7.78 (d, J=15.9 Hz, 1H), 7.64 (d, J=16.2 Hz, 1H), 7.51-7.38 (m, 2H), 7.35 (d, J=3.0 Hz, 1H), 7.18 (dd, J=3.3, 9.0 Hz, 1H), 6.95 (d, J=9.3 Hz, 1H), 4.47-4.35 (m, 4H).

Sources & evidence

ORD record
ord-654f83ce4417429da694e4cc73b9d287
Source dataset
uspto-grants-2007_08
Patent number
US07256219B2

Reaction notes

Loading…