1-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one → HCID 90912329, compound

Participants

Reaction Steps

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and 2,3-difluoro-4-(trifluoromethyl)benzaldehyde (91 ul, 0.633 mmol) similar to Example 18 as a yellow solid (66 mg, 20%). 1H NMR (CDCl3): 7.78 (d, J=15.9 Hz, 1H), 7.64 (d, J=16.2 Hz, 1H), 7.51-7.38 (m, 2H), 7.35 (d, J=3.0 Hz, 1H), 7.18 (dd, J=3.3, 9.0 Hz, 1H), 6.95 (d, J=9.3 Hz, 1H), 4.47-4.35 (m, 4H).

Provenance & Evidence