反应详情

A solution of amide 21 (0.80 g, 0.222 mmol) in THF/MeOH (5 ml/5 ml) was stirred with Raney Nickel (0.150 ml) under H2 atmosphere at room temperature for 2 h. The amine was freed from catalyst by filtration through celite to give 22 (0.065 g, 88%) dried and used as is for the next step.

1. filtrationThe amine was freed from catalyst by filtration through celite