Pyridine-2-carboxylic acid [2-(4-nitro-phenyl)-3H-imidazo[4,5-c]pyridin-6-yl]-amide → Pyridine-2-carboxylic acid [2-(4-amino-phenyl)-3H-imidazo[4,5-c]pyridin-6-yl]-amide

Participants

Reaction Steps

A solution of amide 21 (0.80 g, 0.222 mmol) in THF/MeOH (5 ml/5 ml) was stirred with Raney Nickel (0.150 ml) under H2 atmosphere at room temperature for 2 h. The amine was freed from catalyst by filtration through celite to give 22 (0.065 g, 88%) dried and used as is for the next step.

Provenance & Evidence