2-Hydrazinoethanol → 3-(2-Hydroxyethyl)hydrazono-2-hydroxyiminopropionitrile

Temperature

5 °C

In a similar apparatus used in Example 1 were charged 0.98 g (10 mmol) of 2-hydroxyimino-3-oxopropionitrile synthesized by the same method as in Example 1 and 6 ml of methanol, and the mixture was cooled to 5° C. while stirring. Then, 0.80 g (10 mmol) of 95% by weight 2-hydroxyethylhydrazine was added to the mixture at the same temperature, and reacted at room temperature for 1 hour. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, hexane was added to the concentrate, the resulting mixture was filtered and dried under reduced pressure to give 1.55 g (isolation yield: 99%) of 3-(2-hydroxyethyl)hydrazono-2-hydroxyiminopropionitrile as dark brownish solid.

1. customreacted at room temperature for 1 hour
2. customAfter completion of the reaction
3. concentrationthe reaction mixture was concentrated under reduced pressure, hexane
4. additionwas added to the concentrate
5. filtrationthe resulting mixture was filtered
6. customdried under reduced pressure

ORD record

ord-a3df4c264162493188a6bed6b7109c37

Source dataset

uspto-grants-2007_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07256304B2