Isopropyl iodide → HCID 68210251, compound

HRID 85413Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:11]([O:13][CH3:14])=[O:12])[C:5]2[CH:6]=[N:7][NH:8][C:9]=2[CH:10]=1.[H-].[Na+].I[CH:18]([CH3:20])[CH3:19]>>[F:1][C:2]1[CH:3]=[C:4]([C:11]([O:13][CH3:14])=[O:12])[C:5]2[CH:6]=[N:7][N:8]([CH:18]([CH3:20])[CH3:19])[C:9]=2[CH:10]=1

Participants

Reactant 3

HCID 6362Isopropyl iodide

HCID 24758Sodium hydride

HCID 24728348methyl 6-fluoro-1H-indazole-4-carboxylate

Product 1

HCID 68210251HCID 68210251, compound

Procedure

The title compound was prepared in the same manner as described for example 1 (step a) from methyl 6-fluoro-1H-indazole-4-carboxylate (0.500 g, 2.58 mmol), sodium hydride (0.129 g, 3.22 mmol), and 2-iodopropane (0.386 mL, 3.86 mmol). The product was collected as a yellow solid (0.32 g, 52%); 1H NMR (400 MHz, DMSO-d6) ppm 1.48 (d, J=6.57 Hz, 6H) 3.96 (s, 3H) 5.04 (quin, J=6.57 Hz, 1H) 7.61 (dd, J=9.60, 2.27 Hz, 1H) 8.03 (dt, J=8.46, 1.20 Hz, 1H) 8.41 (s, 1H).

Workup

customThe product was collected as a yellow solid (0.32 g, 52%)

Sources & evidence

ORD record: ord-e853f9d69d594d1e8f2d76f0e9b6aaba
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846935B2

Reaction notes

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