反应详情

To a solution of 1 (0.1 g, 0.35 mmol) in dry DMSO was added dry K2CO3 then methyl iodide and the suspension was shaken at rt. for 2 days. The precipitate formed by addition of water was filtered off then washed with water until neutral pH. The crude residue, dried under vacuum at 40° C., was triturated in warm acetonitrile, filtered off then dried under vacuum at 40° C., affording 5.6 mg (5%) of the title compound as a yellow powder.

1. filtrationwas filtered off
2. washthen washed with water until neutral pH
3. dry with materialThe crude residue, dried under vacuum at 40° C.
4. customwas triturated in warm acetonitrile
5. filtrationfiltered off
6. customthen dried under vacuum at 40° C.