Hydrochloric Acid → HCID 69155509, compound

Participants

Reaction Steps

(3R,6S)-4-[(3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]hexahydro-3,6dimethyl-2H-1,4-diazepin-2-one (135 mg, 0.3 mmol) was treated with 4N hydrogen chloride in dioxane (2 mL) at room temperature for 2 hr. The solvent was removed under a stream of nitrogen, and the crude product was purified on preparative TLC plates (silica, 10% 2N ammonia/methanol in dichloromethane) to yield the title compound as white solid. MS (M+1): 358.2.

Provenance & Evidence