Hydrochloric Acid → HCID 69155509, compound

HRID 854286Notes

Reaction equation

HRID 854286 reaction equation
C(OC([NH:8][C@H:9]([CH2:23][C:24]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=1[F:32])[CH2:10][C:11]([N:13]1[CH2:19][C@@H:18]([CH3:20])[CH2:17][NH:16][C:15](=[O:21])[C@H:14]1[CH3:22])=[O:12])=O)(C)(C)C.[ClH:33]>O1CCOCC1>[ClH:33].[NH2:8][C@H:9]([CH2:23][C:24]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=1[F:32])[CH2:10][C:11]([N:13]1[CH2:19][C@@H:18]([CH3:20])[CH2:17][NH:16][C:15](=[O:21])[C@H:14]1[CH3:22])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69155362HCID 69155362, compound

Product 1

HCID 69155509HCID 69155509, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(3R,6S)-4-[(3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]hexahydro-3,6dimethyl-2H-1,4-diazepin-2-one (135 mg, 0.3 mmol) was treated with 4N hydrogen chloride in dioxane (2 mL) at room temperature for 2 hr. The solvent was removed under a stream of nitrogen, and the crude product was purified on preparative TLC plates (silica, 10% 2N ammonia/methanol in dichloromethane) to yield the title compound as white solid. MS (M+1): 358.2.

Workup

  1. customThe solvent was removed under a stream of nitrogen
  2. customthe crude product was purified on preparative TLC plates (silica, 10% 2N ammonia/methanol in dichloromethane)

Sources & evidence

ORD record
ord-2564d686fa5743e0ab033c2626837f51
Source dataset
uspto-grants-2007_08
Patent number
US07259160B2

Reaction notes

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