HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58933876, compound → 2-Amino-pyrimidine-5-carboxylic acid [1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58933876 | HCID 58933876 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Amino-pyrimidine-5-carboxylic acid [1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amide | HCID 10111788 | — |
Reaction Steps
2-Amino-pyrimidine-5-carboxylic acid [1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amide was prepared from (5-{[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-carbamoyl}-pyrimidin-2-yl)-carbamic acid tert-butyl ester by stirring at rt for 3 h in 4N HCl in dioxane. The product was precipitated as the hydrochloride salt by dilution with ether and filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259157B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-3e0d46cf07cc49ab9c7ed869887c2c3e |
| Source note | uspto-grants-2007_08 |