HCID 58933876, compound → 2-Amino-pyrimidine-5-carboxylic acid [1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amide

HRID 854313Notes

Reaction equation

HRID 854313 reaction equation
C(OC(=O)[NH:7][C:8]1[N:13]=[CH:12][C:11]([C:14](=[O:34])[NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([S:23]([CH2:26][CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)(=[O:25])=[O:24])[CH2:19][CH2:18]2)=[CH:10][N:9]=1)(C)(C)C>Cl.O1CCOCC1>[C:28]1([CH2:27][CH2:26][S:23]([N:20]2[CH2:21][CH2:22][CH:17]([CH2:16][NH:15][C:14]([C:11]3[CH:12]=[N:13][C:8]([NH2:7])=[N:9][CH:10]=3)=[O:34])[CH2:18][CH2:19]2)(=[O:25])=[O:24])[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

4

Reactant 1

HCID 58933876HCID 58933876, compound

Product 1

HCID 101117882-Amino-pyrimidine-5-carboxylic acid [1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amide

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

2-Amino-pyrimidine-5-carboxylic acid [1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amide was prepared from (5-{[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-carbamoyl}-pyrimidin-2-yl)-carbamic acid tert-butyl ester by stirring at rt for 3 h in 4N HCl in dioxane. The product was precipitated as the hydrochloride salt by dilution with ether and filtration.

Workup

  1. customThe product was precipitated as the hydrochloride salt by dilution with ether and filtration

Sources & evidence

ORD record
ord-3e0d46cf07cc49ab9c7ed869887c2c3e
Source dataset
uspto-grants-2007_08
Patent number
US07259157B2

Reaction notes

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