反应详情

2-Amino-pyrimidine-5-carboxylic acid [1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amide was prepared from (5-{[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-carbamoyl}-pyrimidin-2-yl)-carbamic acid tert-butyl ester by stirring at rt for 3 h in 4N HCl in dioxane. The product was precipitated as the hydrochloride salt by dilution with ether and filtration.

1. customThe product was precipitated as the hydrochloride salt by dilution with ether and filtration