Thiazole-4-carboxaldehyde → 2-[N-(1,3-Thiazol-4-ylmethylene)amino]-3-(pyridin-2-yl)propionic acid, tert-butyl ester

HRID 854348Notes

Reaction equation

HRID 854348 reaction equation
[S:1]1[CH:5]=[C:4]([CH:6]=O)[N:3]=[CH:2]1.[NH2:8][CH:9]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]>>[S:1]1[CH:5]=[C:4]([CH:6]=[N:8][CH:9]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)[C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 2763214Thiazole-4-carboxaldehydeHCID 83225413Tert-butyl 2-amino-3-(pyridin-2-yl)propanoate

Product 1

HCID 865966932-[N-(1,3-Thiazol-4-ylmethylene)amino]-3-(pyridin-2-yl)propionic acid, tert-butyl ester

Procedure

Prepared in a similar manner to that described for Intermediate 1, replacing 2-amino-4-methyl-pentanoic acid tert-butyl ester, hydrochloride with 2-amino-3-(2-pyridyl) propionic acid, tert-butyl ester.

Workup

  1. customPrepared in a similar manner to that

Sources & evidence

ORD record
ord-380345d722db4edf8ab11345a681b4f1
Source dataset
uspto-grants-2007_08
Patent number
US07259163B2

Reaction notes

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