Trifluoroacetic acid → HCID 10166359, compound

HRID 854352Notes

Reaction equation

[C:1]([C:5]1[CH:40]=[CH:39][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[S:20][C:19]([Cl:21])=[N:18][CH:17]=3)[C@@H:14]([C:22]3[CH:27]=[N:26][CH:25]=[CH:24][N:23]=3)[CH2:13][C@@:12]2([CH2:35][CH:36]([CH3:38])[CH3:37])[C:28]([O:30]C(C)(C)C)=[O:29])=[O:10])=[CH:7][C:6]=1[O:41][CH3:42])([CH3:4])([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>>[C:1]([C:5]1[CH:40]=[CH:39][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[S:20][C:19]([Cl:21])=[N:18][CH:17]=3)[C@@H:14]([C:22]3[CH:27]=[N:26][CH:25]=[CH:24][N:23]=3)[CH2:13][C@@:12]2([CH2:35][CH:36]([CH3:37])[CH3:38])[C:28]([OH:30])=[O:29])=[O:10])=[CH:7][C:6]=1[O:41][CH3:42])([CH3:3])([CH3:4])[CH3:2]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 69357090HCID 69357090, compound

Product 1

HCID 10166359HCID 10166359, compound

Procedure

The tert-butyl ester from stage A was deprotected with TFA in a similar manner to that described in Example 1, to afford the title compound as a solid.

Sources & evidence

ORD record: ord-057b7f807b65434dad9ba4b27a296dd7
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07259163B2

Reaction notes

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