Trifluoroacetic acid → HCID 10275919, compound

HRID 854356Notes

Reaction equation

[C:1]([C:5]1[CH:35]=[CH:34][C:8]([C:9]([N:11]2[C@@H:15]([CH3:16])[C@@H:14]([C:17]3[CH:22]=[N:21][CH:20]=[CH:19][N:18]=3)[CH2:13][C@@:12]2([CH2:30][CH:31]([CH3:33])[CH3:32])[C:23]([O:25]C(C)(C)C)=[O:24])=[O:10])=[CH:7][C:6]=1[O:36][CH3:37])([CH3:4])([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>>[C:1]([C:5]1[CH:35]=[CH:34][C:8]([C:9]([N:11]2[C@@H:15]([CH3:16])[C@@H:14]([C:17]3[CH:22]=[N:21][CH:20]=[CH:19][N:18]=3)[CH2:13][C@@:12]2([CH2:30][CH:31]([CH3:32])[CH3:33])[C:23]([OH:25])=[O:24])=[O:10])=[CH:7][C:6]=1[O:36][CH3:37])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 131726555HCID 131726555, compound

Product 1

HCID 10275919HCID 10275919, compound

Procedure

The tert-butyl ester from stage A was deprotected with TFA in a similar manner to that described in Example 1, to afford the title compound as a solid.

Sources & evidence

ORD record: ord-a31d20e8da2044bb819d9f14068bea84
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07259163B2

Reaction notes

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