Trifluoroacetic acid → HCID 10188029, compound

HRID 854358Notes

Reaction equation

[C:1]([C:5]1[CH:42]=[CH:41][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[N:17]=[C:18]([N:21]([CH3:23])[CH3:22])[S:19][CH:20]=3)[C@@H:14]([C:24]3[CH:29]=[N:28][CH:27]=[CH:26][N:25]=3)[CH2:13][C@@:12]2([CH2:37][CH:38]([CH3:40])[CH3:39])[C:30]([O:32]C(C)(C)C)=[O:31])=[O:10])=[CH:7][C:6]=1[O:43][CH3:44])([CH3:4])([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>>[C:1]([C:5]1[CH:42]=[CH:41][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[N:17]=[C:18]([N:21]([CH3:23])[CH3:22])[S:19][CH:20]=3)[C@@H:14]([C:24]3[CH:29]=[N:28][CH:27]=[CH:26][N:25]=3)[CH2:13][C@@:12]2([CH2:37][CH:38]([CH3:39])[CH3:40])[C:30]([OH:32])=[O:31])=[O:10])=[CH:7][C:6]=1[O:43][CH3:44])([CH3:3])([CH3:4])[CH3:2]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 131726557HCID 131726557, compound

Product 1

HCID 10188029HCID 10188029, compound

Procedure

The tert-butyl ester from stage A was deprotected with TFA in a similar manner to that described in Example 1, to afford the title compound as a solid.

Sources & evidence

ORD record: ord-24d04c172f8840f5af5d3875d345b6db
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07259163B2

Reaction notes

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