Trifluoroacetic acid → HCID 10166527, compound

HRID 854361Notes

Reaction equation

[C:1]([C:5]1[CH:46]=[CH:45][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:17]=3)[C@@H:14]([C:28]3[CH:33]=[N:32][CH:31]=[CH:30][N:29]=3)[CH2:13][C@@:12]2([CH2:41][CH:42]([CH3:44])[CH3:43])[C:34]([O:36]C(C)(C)C)=[O:35])=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:17]=3)[C@@H:14]([C:28]3[CH:33]=[N:32][CH:31]=[CH:30][N:29]=3)[CH2:13][C@@:12]2([CH2:41][CH:42]([CH3:43])[CH3:44])[C:34]([OH:36])=[O:35])=[O:10])=[CH:45][CH:46]=1)([CH3:3])([CH3:2])[CH3:4]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 58934034HCID 58934034, compound

Product 1

HCID 10166527HCID 10166527, compound

Procedure

The tert-butyl ester from stage A was deprotected with TFA in a similar manner to that described in Example 1, to afford the title compound as a solid.

Sources & evidence

ORD record: ord-382c299a46d240378978f17e9d71d8fe
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07259163B2

Reaction notes

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