Trifluoroacetic acid → HCID 10209716, compound

HRID 854363Notes

Reaction equation

[C:1]([C:5]1[CH:43]=[CH:42][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[CH:21]=[CH:20][C:19]([N:22]([CH3:24])[CH3:23])=[CH:18][CH:17]=3)[C@@H:14]([C:25]3[CH:30]=[N:29][CH:28]=[CH:27][N:26]=3)[CH2:13][C@@:12]2([CH2:38][CH:39]([CH3:41])[CH3:40])[C:31]([O:33]C(C)(C)C)=[O:32])=[O:10])=[CH:7][C:6]=1[O:44][CH3:45])([CH3:4])([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>>[C:1]([C:5]1[CH:43]=[CH:42][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[CH:17]=[CH:18][C:19]([N:22]([CH3:23])[CH3:24])=[CH:20][CH:21]=3)[C@@H:14]([C:25]3[CH:30]=[N:29][CH:28]=[CH:27][N:26]=3)[CH2:13][C@@:12]2([CH2:38][CH:39]([CH3:40])[CH3:41])[C:31]([OH:33])=[O:32])=[O:10])=[CH:7][C:6]=1[O:44][CH3:45])([CH3:3])([CH3:4])[CH3:2]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 131726559HCID 131726559, compound

Product 1

HCID 10209716HCID 10209716, compound

Procedure

The tert-butyl ester from stage A was deprotected with TFA in a similar manner to that described in Example 1, to afford the title compound as a solid

Sources & evidence

ORD record: ord-79ad603aa86a4598b700334287f229ad
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07259163B2

Reaction notes

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