Trifluoroacetic acid → HCID 69355879, compound

HRID 854372Notes

Reaction equation

[C:1]([C:5]1[CH:36]=[CH:35][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[S:20][CH:19]=[N:18][CH:17]=3)[C@@H:14]([N:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH2:22]3)[CH2:13][C@@:12]2([CH3:34])[C:27]([O:29]C(C)(C)C)=[O:28])=[O:10])=[CH:7][C:6]=1[Cl:37])([CH3:4])([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>>[C:1]([C:5]1[CH:36]=[CH:35][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[S:20][CH:19]=[N:18][CH:17]=3)[C@@H:14]([N:21]3[CH:22]=[CH:23][N:24]=[CH:25][CH2:26]3)[CH2:13][C@@:12]2([CH3:34])[C:27]([OH:29])=[O:28])=[O:10])=[CH:7][C:6]=1[Cl:37])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 131726565HCID 131726565, compound

Product 1

HCID 69355879HCID 69355879, compound

Procedure

The tert-butyl ester from stage A was deprotected with TFA in a similar manner to that described in Example 1 to afford the title compound as a solid.

Sources & evidence

ORD record: ord-0821f37ecd5c4458b916472000e4078c
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07259163B2

Reaction notes

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