Trifluoroacetic acid → HCID 10120641, compound

HRID 854374Notes

Reaction equation

[C:1]([C:5]1[CH:45]=[CH:44][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[N:17]=[C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[S:19][CH:20]=3)[C@@H:14]([C:27]3[CH:32]=[N:31][CH:30]=[CH:29][N:28]=3)[CH2:13][C@@:12]2([CH2:40][CH:41]([CH3:43])[CH3:42])[C:33]([O:35]C(C)(C)C)=[O:34])=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>>[C:1]([C:5]1[CH:45]=[CH:44][C:8]([C:9]([N:11]2[C@@H:15]([C:16]3[N:17]=[C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[S:19][CH:20]=3)[C@@H:14]([C:27]3[CH:32]=[N:31][CH:30]=[CH:29][N:28]=3)[CH2:13][C@@:12]2([CH2:40][CH:41]([CH3:42])[CH3:43])[C:33]([OH:35])=[O:34])=[O:10])=[CH:7][CH:6]=1)([CH3:3])([CH3:2])[CH3:4]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 131726567HCID 131726567, compound

Product 1

HCID 10120641HCID 10120641, compound

Procedure

The tert-butyl ester from stage A was deprotected with TFA in a similar manner to that described in Example 1 and purified by reverse phase HPLC to afford the title compound as a solid.

Workup

custompurified by reverse phase HPLC

Sources & evidence

ORD record: ord-887e4d64ba664d778d48c61cadb6cad2
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07259163B2

Reaction notes

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