1-Methylpiperazine → 5-[(4-Methylpiperazin-1-yl)carbonyl]-1H-benzimidazole

HRID 854463Notes

Reaction equation

HRID 854463 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[NH:3][CH:2]=1.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:10]([C:8]2[CH:7]=[CH:6][C:5]3[NH:1][CH:2]=[N:3][C:4]=3[CH:9]=2)=[O:12])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 4594565-Benzimidazolecarboxylic acid

Product 1

HCID 1784810345-[(4-Methylpiperazin-1-yl)carbonyl]-1H-benzimidazoleYield 63%

Procedure

In a procedure analogous to example 20, reaction of benzimidazole-5-carboxylic acid (400 mg, 2.50 mmol) and N-methylpiperazine (550 mg, 5.0 mmol) furnished the product (380 mg, 63%).

Sources & evidence

ORD record
ord-6137a4f622b9433284ef3ff8c0758efd
Source dataset
uspto-grants-2007_08
Patent number
US07259179B2

Reaction notes

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