2,6-Dichloropyrazine → HCID 58717083, compound

HRID 854471Notes

Reaction equation

HRID 854471 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([CH:7]([NH2:9])[CH3:8])=[CH:5][CH:4]=1.[Cl:12][C:13]1[CH:18]=[N:17][CH:16]=[C:15](Cl)[N:14]=1>>[Cl:12][C:13]1[N:14]=[C:15]([NH:9][C@H:7]([C:6]2[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH3:8])[CH:16]=[N:17][CH:18]=1

Participants

3

Reactant 2

HCID 785042,6-DichloropyrazineHCID 2381811-(4-Methoxyphenyl)ethanamine

Product 1

HCID 58717083HCID 58717083, compoundYield 79%

Procedure

In a procedure analogous to example 1, reaction of 4-methoxy-α-methyl-benzylamine (700 mg, 4.6 mmol) and 2,6-dichloropyrazine (626 mg, 4.2 mmol) furnished the product (873 mg, 79%).

Sources & evidence

ORD record
ord-1f0f5c035df24d6a90da190d1397fd9c
Source dataset
uspto-grants-2007_08
Patent number
US07259179B2

Reaction notes

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