反应详情

To a solution of 5-Chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole (0.51 g, 1.73 mmol) in acetone is added NaI (0.42 g, 2.80 mmol). The mixture is stirred at RT for 3 h. The solid is filtered, and the filtrate is concentrated. The resulting solid is washed with Et2O and refiltered. Concentration of the filtrate yielded the title compound (0.68 g, quant.). The material is used without further purification.

1. filtrationThe solid is filtered
2. concentrationthe filtrate is concentrated
3. washThe resulting solid is washed with Et2O