2-Naphthalenecarboxaldehyde → 4-Iodomethyl-5-methyl-2-naphthalen-2-yloxazole

HRID 854636Notes

Reaction equation

HRID 854636 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1C=CC=CC=1.[CH3:21][C:22](=NO)[C:23](=O)C.C1C2C(=CC=CC=2)C=CC=1C=O>>[CH3:8][C:7]1[O:6][C:5]([C:14]2[CH:15]=[CH:16][C:17]3[C:18](=[CH:21][CH:22]=[CH:23][CH:20]=3)[CH:19]=2)=[N:4][C:3]=1[CH2:2][I:1]

Participants

4

Reactant 3

HCID 62012-NaphthalenecarboxaldehydeHCID 63989692-Oxime 2,3-butanedioneHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 210742684-Iodomethyl-5-methyl-2-naphthalen-2-yloxazole

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, butane-2,3-dione-2-oxime and naphthalene-2-carbaldehyde gave 5-methyl-4-iodomethyl-2-naphthalen-2-yloxazole.

Sources & evidence

ORD record
ord-3669f51637864241a313163f01b1b3b5
Source dataset
uspto-grants-2007_08
Patent number
US07259177B2

Reaction notes

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