HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (cis-3-Methoxymethoxycyclohexyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Methyl cis-3-methoxymethoxycyclohexanecarboxylate | HCID 69240434 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (cis-3-Methoxymethoxycyclohexyl)methanol | HCID 69240471 | 90.3% |
Reaction Steps
9.0 g of methyl cis-3-methoxymethoxycyclohexanecarboxylate are dissolved in 280 ml of diethyl ether, 2.2 g of LiAlH4 are added and the mixture is stirred at room temperature. After 4 h, at 0° C., 10 ml of ethyl acetate and then 15 ml of 10N NaOH are added dropwise. The suspension is stirred for 1 h, MgSO4 is added, the mixture is filtered through Celite and the filtrate is concentrated, giving 7.0 g of (cis-3-methoxymethoxycyclo-hexyl)methanol as a colorless oil. C9H18O3 (174), MS(ESI): 175 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259177B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-54c0286b70de41eba438c2483540c26f |
| Source note | uspto-grants-2007_08 |