反应详情

9.0 g of methyl cis-3-methoxymethoxycyclohexanecarboxylate are dissolved in 280 ml of diethyl ether, 2.2 g of LiAlH4 are added and the mixture is stirred at room temperature. After 4 h, at 0° C., 10 ml of ethyl acetate and then 15 ml of 10N NaOH are added dropwise. The suspension is stirred for 1 h, MgSO4 is added, the mixture is filtered through Celite and the filtrate is concentrated, giving 7.0 g of (cis-3-methoxymethoxycyclo-hexyl)methanol as a colorless oil. C9H18O3 (174), MS(ESI): 175 (MH+).

1. stirringThe suspension is stirred for 1 h
2. filtrationthe mixture is filtered through Celite
3. concentrationthe filtrate is concentrated