1,3-Dichloroacetone → HCID 86598514, compound

HRID 854682Notes

Reaction equation

HRID 854682 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11](=[S:13])[NH2:12])=[CH:5][CH:4]=1.[Cl:16][CH2:17][C:18]([CH2:20]Cl)=[O:19]>CC(C)=O>[ClH:16].[Cl:16][CH2:17][C:18](=[O:19])[CH2:20][S:13][C:11](=[NH:12])[CH:10]=[CH:9][C:6]1[CH:7]=[CH:8][C:3]([C:2]([F:1])([F:14])[F:15])=[CH:4][CH:5]=1

Participants

4

Reactant 2

HCID 107931,3-DichloroacetoneHCID 86047535HCID 86047535, compound

Product 1

HCID 86598514HCID 86598514, compoundYield 70.1%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2.30 g (9.95 mmol) 3-(4-Trifluoromethyl-phenyl)-acrylthioamide, 2.52 g (19.90 mmol) 1,3-dichloroacetone and 75 ml acetone were stirred at room temperature for 24 h. The precipitate was isolated and dried, yielding 2.50 g (70%) 3-(4-trifluoromethyl-phenyl)-thioacrylimidic acid 3-chloro-2-oxo-propyl ester hydrochloride.

Workup

  1. customThe precipitate was isolated
  2. customdried

Sources & evidence

ORD record
ord-f3a8ef4f8d9e4484910215e40bca7331
Source dataset
uspto-grants-2007_08
Patent number
US07259262B2

Reaction notes

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