4-Chlorobenzoyl chloride → HCID 69517098, compound

HRID 854967Notes

Reaction equation

HRID 854967 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[C:13]([CH3:17])([CH3:16])[CH2:14][NH2:15])[O:9][CH:8]([C:18]([F:21])([F:20])[F:19])[C:7]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:6]2.[Cl:27][C:28]1[CH:36]=[CH:35][C:31]([C:32](Cl)=[O:33])=[CH:30][CH:29]=1.C(F)(F)(C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)N(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>N1C=CC=CC=1.C(Cl)Cl>[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[C:13]([CH3:16])([CH3:17])[CH2:14][NH:15][C:32](=[O:33])[C:31]1[CH:35]=[CH:36][C:28]([Cl:27])=[CH:29][CH:30]=1)[O:9][CH:8]([C:18]([F:21])([F:20])[F:19])[C:7]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:6]2

Participants

6

Reactant 3

HCID 85014-Chlorobenzoyl chlorideHCID 67646Fluorocarbon FC 70HCID 69519193HCID 69519193, compound

Product 1

HCID 69517098HCID 69517098, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of the title product of Example 130 Step 1 (150 mg, 0.397 mmole) in 5 mL of pyridine was added a solution of 4-chlorobenzoyl chloride (90 mg, 0.51 mmole) in 1 mL of DCM. The mixture was stirred for 2 h, and 750 mg of Tris amine resin was added. After stirring overnight, the mixture was filtered and concentrated to give the title compound, which was used as is for the next step.

Workup

  1. stirringAfter stirring overnight
  2. filtrationthe mixture was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-a003fd8bc2ef4e5abc213f16502b5208
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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