Sodium Hydroxide → 7-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid

HRID 854972Notes

Reaction equation

HRID 854972 reaction equation
[I:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:16]([O:18]CC)=[O:17])[CH:8]([C:12]([F:15])([F:14])[F:13])[O:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>CCO.O>[I:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:16]([OH:18])=[O:17])[CH:8]([C:12]([F:14])([F:13])[F:15])[O:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 69517680ethyl 7-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Product 1

HCID 695190647-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a suspension of ethyl 7-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate (1.50 g, 3.9 mmol) in 5 mL EtOH was added NaOH (0.46 g, 11.6 mmol) in 2.5 mL of H2O. After heating for 1.5 h, reaction solvent was removed under vacuum. The resulting sodium salt was used immediately.

Workup

  1. temperatureAfter heating for 1.5 h
  2. customreaction solvent
  3. customwas removed under vacuum

Sources & evidence

ORD record
ord-e1a1f709910f401e8a5b13b219ab1d36
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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