HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 7-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | ethyl 7-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate | HCID 69517680 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid | HCID 69519064 | — |
Reaction Steps
To a suspension of ethyl 7-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate (1.50 g, 3.9 mmol) in 5 mL EtOH was added NaOH (0.46 g, 11.6 mmol) in 2.5 mL of H2O. After heating for 1.5 h, reaction solvent was removed under vacuum. The resulting sodium salt was used immediately.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259266B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-e1a1f709910f401e8a5b13b219ab1d36 |
| Source note | uspto-grants-2007_08 |