Sodium Hydroxide → HCID 69517256, compound

HRID 855042Notes

Reaction equation

HRID 855042 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH3:20])=[CH:15][CH:14]=1)[O:8][CH:7]([C:21]([F:24])([F:23])[F:22])[C:6]([C:25]([OH:27])=[O:26])=[CH:5]2.[OH-].[Na+:29]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH3:20])=[CH:17][CH:18]=1)[O:8][CH:7]([C:21]([F:24])([F:22])[F:23])[C:6]([C:25]([O-:27])=[O:26])=[CH:5]2.[Na+:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11153766HCID 11153766, compound

Product 1

HCID 69517256HCID 69517256, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 47.6 mg (0.119 mmole) of 6-chloro-7-(4-ethylphenoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid in 1.5 mL of ethanol was treated with 1.18 mL of 0.1008N NaOH. The resultant mixture was lyophilized to provide 51 mg (quant.) of an off-white solid: 1H NMR (CD3OD/400 MHz) 1.25 (t, 3H, J=7.7 Hz), 2. 68 (q, 2H, J=7.7 Hz), 5.79 (q, 1H, J=7.2 Hz), 6.92 (d, 2H, J=8.6 Hz), 7.25 (d, 2H, J=8.6 Hz), 7.37 (m, 2H); MS (ES+) 399 (M+1, 100).

Workup

  1. customto provide 51 mg (quant.) of an off-white solid

Sources & evidence

ORD record
ord-97e10199de4a46f49a7ffe09523ab2a1
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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