Sodium Hydroxide → HCID 69516435, compound

HRID 855043Notes

Reaction equation

HRID 855043 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[O:9][CH:8]([C:15]([F:18])([F:17])[F:16])[C:7]([C:19]([OH:21])=[O:20])=[CH:6]2)[CH3:2].[OH-].[Na+:23]>C(O)C>[CH2:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[O:9][CH:8]([C:15]([F:16])([F:17])[F:18])[C:7]([C:19]([O-:21])=[O:20])=[CH:6]2)[CH3:2].[Na+:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11289626HCID 11289626, compound

Product 1

HCID 69516435HCID 69516435, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To the solution of 0.785 g (2.51 mm) of 6-ethyl-7-methoxy-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid in 20 mL of ethanol was added 24.9 mL of 0.1008 N aqueous solution of sodium hydroxide. The resulting solution was stirred at room temperature for half an hour. The volatiles were removed. The residue was dissolved in 20 mL of water. The resulting solution was frozen and lyophilized to give a light yellow solid. LC-MS (ES−) 301 (M−H, 100). HRMS (ES−) m/z calcd for (M−1; C14H12F3O4) 301.0790, found 301.0810.

Workup

  1. customThe volatiles were removed
  2. dissolutionThe residue was dissolved in 20 mL of water
  3. temperatureThe resulting solution was frozen
  4. customto give a light yellow solid

Sources & evidence

ORD record
ord-6c0d5f98fb0a4ecb8fc2f6bb8f6197e8
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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