Sodium Hydroxide → HCID 69517861, compound

HRID 855044Notes

Reaction equation

HRID 855044 reaction equation
[Cl:1][C:2]1[C:3]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH:7]([C:12]([F:15])([F:14])[F:13])[C:6]([C:16]([OH:18])=[O:17])=[CH:5]2.[OH-].[Na+:27]>C(O)C>[Cl:1][C:2]1[C:3]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH:7]([C:12]([F:15])([F:13])[F:14])[C:6]([C:16]([O-:18])=[O:17])=[CH:5]2.[Na+:27]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53324322HCID 53324322, compound

Product 1

HCID 69517861HCID 69517861, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 110 mg (0.297 mmole) of 6-chloro-5-phenoxy-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid in 3.0 mL of ethanol was treated with 2.94 mL of 0.1008N NaOH. The resultant mixture was lyophilized to provide 116 mg (quant.) of an off-white solid: 1H NMR (CD3OD/400 MHz) 5.90 (q, 1H, J=7.2 Hz), 6.81 (d, 2H, J=8.3 Hz), 6.93 (d, 1H, J=8.9 Hz) 7.05 (t, 1H, J=7.5 Hz), 7.32 (t, 2H, J=8.6 Hz), 7.42 (d, 1H, J=8.9 H), 7.56 (s, 1H); MS (ES+) 371 (M+1, 100).

Workup

  1. customto provide 116 mg (quant.) of an off-white solid

Sources & evidence

ORD record
ord-1d90659d760c4b19985b22a7d6b2c904
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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