Sodium Hydroxide → HCID 69517861, compound

Participants

Reaction Steps

A solution of 110 mg (0.297 mmole) of 6-chloro-5-phenoxy-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid in 3.0 mL of ethanol was treated with 2.94 mL of 0.1008N NaOH. The resultant mixture was lyophilized to provide 116 mg (quant.) of an off-white solid: 1H NMR (CD3OD/400 MHz) 5.90 (q, 1H, J=7.2 Hz), 6.81 (d, 2H, J=8.3 Hz), 6.93 (d, 1H, J=8.9 Hz) 7.05 (t, 1H, J=7.5 Hz), 7.32 (t, 2H, J=8.6 Hz), 7.42 (d, 1H, J=8.9 H), 7.56 (s, 1H); MS (ES+) 371 (M+1, 100).

Provenance & Evidence