Sodium Hydroxide → HCID 69516934, compound

HRID 855173Notes

Reaction equation

HRID 855173 reaction equation
[CH2:1]([C:3]1[CH:27]=[CH:26][C:6]([O:7][C:8]2[C:17]([CH3:18])=[C:16]3[C:11]([CH:12]=[C:13]([C:23]([OH:25])=[O:24])[CH:14]([C:19]([F:22])([F:21])[F:20])[O:15]3)=[CH:10][CH:9]=2)=[CH:5][CH:4]=1)[CH3:2].[OH-].[Na+:29]>C(O)C>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([O:7][C:8]2[C:17]([CH3:18])=[C:16]3[C:11]([CH:12]=[C:13]([C:23]([O-:25])=[O:24])[CH:14]([C:19]([F:20])([F:22])[F:21])[O:15]3)=[CH:10][CH:9]=2)=[CH:26][CH:27]=1)[CH3:2].[Na+:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69516862HCID 69516862, compound

Product 1

HCID 69516934HCID 69516934, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 7-(4-ethylphenoxy)-8-methyl-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid 40.3 mg (0.107 mmole) in 2.0 mL of ethanol was treated with 1.057 mL of 0.1008N NaOH. The resultant mixture was lyophilized to provide a quantitative yield of a yellow solid: 1H NMR (CD3OD/400 MHz) 1.21 (t, 3H, J=7.6 Hz), 2.12 (s, 3H), 2.61 (q, 2H, J=7.6 Hz), 5.87 (q, 1H, J=7.2 Hz), 6.38 (d, 1H, J=8.0 Hz), 6.84 (d, 2H, J=8.0 Hz), 7.00 (d, 1H), J=8.0 Hz), 7.17 (d, 2H, J=8.0 Hz), 7.40 (s, 1H).

Sources & evidence

ORD record
ord-a07897906c704072af6a9723dd497caa
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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