Sodium Hydroxide → HCID 69346032, compound

HRID 855267Notes

Reaction equation

HRID 855267 reaction equation
ClC1C=C2C(=C(C(O)=O)C=1)NC(C)=C2.C[O:16][C:17]([C:19]1[CH:20]=[C:21]([Cl:30])[CH:22]=[C:23]2[C:27]=1[NH:26][C:25]([CH2:28][CH3:29])=[CH:24]2)=[O:18].[OH-].[Na+]>CO>[Cl:30][C:21]1[CH:22]=[C:23]2[C:27](=[C:19]([C:17]([OH:18])=[O:16])[CH:20]=1)[NH:26][C:25]([CH2:28][CH3:29])=[CH:24]2

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 693469145-chloro-2-methyl-1H-indole-7-carboxylic acidHCID 69347479HCID 69347479, compound

Product 1

HCID 69346032HCID 69346032, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was synthesized in analogy to 5-chloro-2-methyl-1H-indole-7-carboxylic acid (described in example S85) using 5-chloro-2-ethyl-1H-indole-7-carboxylic acid methyl ester (80 mg, 0.34 mmol) and 1N NaOH(aq) (505 μl, 0.51 mmol) in MeOH (5 ml). The desired product (74 mg, 98%) was isolated without further purification. MS (ISP) 222.3 (M−H)−.

Sources & evidence

ORD record
ord-94969870fd9a4ba49ab45d092e26c9d8
Source dataset
uspto-grants-2007_08
Patent number
US07259183B2

Reaction notes

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